Research Institute for Sustainable Humanosphere

第243回定例オープンセミナー
Effects of normothermic conditioned microwave irradiation on cancer cells — aiming to develop novel cancer therapies
マイクロ波精密照射による癌治療の確立に向けて

開催日時 2019(平成31)年1月30日(水) 12:30–13:20
開催場所 総合研究実験1号棟5階 HW525
発表者 浅野麻実子 (京都大学生存圏研究所・ミッション専攻研究員)
関連ミッション ミッション5 高品位生存圏

ZOOM Meeting ID: 215-314-2974

要旨

Cancer is the leading cause of mortality in Japan, and various cancer therapies have been developed to improve patient survival rate. Representative treatments are surgery, chemotherapy, and radiation therapy, and often a combination of these. However, these treatment modalities have several limitations, such as severe side effects and recurrence.

Microwaves, a type of electromagnetic wave, can efficiently generate heat in target substances. Microwaves have been utilized in cancer therapies as a tool for heating cancer cells to a high temperature. Recently, it has become possible to irradiate microwaves to substances with precise control of temperature, output and frequency. In this study, we induced cancer cell death using normothermic conditioned microwave irradiation, wherein the temperature of cancer cells was maintained at 37 °C (Fig. 1). If this could be applied as a cancer therapy, the treatment efficacy would be improved, and heat-related side effects would be avoided.

In this talk, I will first outline the current cancer therapies that involve the use of microwaves. Then, I will introduce our work, which involves the development of a microwave irradiation system and the elucidation of the cell death mechanism induced by this method.

Seminar-0243_AsanoFigure 1: Viability of cultured cells under microwave irradiation. (Asano M et. al., Sci. Rep., 7, 41244, 2017.)
Microwave irradiation was applied for 1 h with the temperature of the cultured cells maintained at 37 °C, whereas the temperature inside the applicator was set at 10 °C. After the irradiation ceased, cells were moved to a CO2 incubator and incubated for 24, 48, or 72 h. Cellular viability was determined using the WST-8 assay. Rates are shown relative to the absorbance of negative control cells, whose values were defined as “100”. The horizontal axes indicate the duration of incubation after irradiation. Data are expressed as the mean ± SD of four independent experiments. Asterisks indicate significant differences from the negative control: *P < 0.05, **P < 0.01.

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