Cellulose synthase and formation of microfibril

Cellulose molecules are synthesized by membrane-anchored terminal complexes (TCs) under simultaneous polymerization and crystallization process. This regulated process yields a microfibril wherein all the chains are packed in a parallel manner. In addition, behavior shape, mode of aggregation, crystalline allomophs and uniplanar orientation have been related to the mode of biogenesis. However, the exact mechanism how organism regulates structure of cellulose is still debated.

Establishment of in vitro cellulose synthesizing setup is requisite to understand the structure and mechanism of cellulose synthases.

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Imai, T. Sun, S.-J., Horikawa, Y., Wada, M., Sugiyama, J., “Functional Reconstitution of Cellulose Synthase in Escherichia coli”, Biomacromolecules, 15, no.11, 4206–4213, 2014.